A passenger plane carrying 116 people is feared to have crashed on a flight from Burkina Faso to the Algerian capital Algiers.
Contact with the Air Algerie flight was lost over the Sahara as it crossed Mali in bad weather, officials said.
French Foreign Minister Laurent Fabius said the plane, which has 50 French citizens aboard, "probably crashed".
French media reported that soldiers had found wreckage in Tilemsi, central Mali, but this was not confirmed.
Contact with Flight AH 5017, chartered from Spanish airline Swiftair, was lost about 50 minutes after take-off from Ouagadougou, Air Algerie said.
The pilot had contacted Niger's control tower in Niamey to change course because of a storm, officials say.
Speaking in Paris, Mr Fabius said: "Despite intensive search efforts no trace of the aircraft has yet been found. The plane probably crashed."
He said French Mirage fighter planes were scouring the area.
Earlier, an Algerian official told Reuters that the plane had crashed, but gave no further details.
France's civil aviation body said crisis centres had been set up at airports in Paris and Marseille.
An Air Algerie spokesman quoted by Reuters said the provisional passenger list included 50 French citizens, 24 people from Burkina Faso, eight Lebanese, four Algerians, two from Luxembourg, one Belgian, one Swiss, one Nigerian, one Cameroonian, one Ukrainian and one Romanian.
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